FGF2

FGF2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1BAS, 1BFB, 1BFC, 1BFF, 1BFG, 1BLA, 1BLD, 1CVS, 1EV2, 1FGA, 1FQ9, 1II4, 1IIL, 2BFH, 2FGF, 2M49, 4FGF, 4OEE, 4OEF, 4OEG
Identifikatori
Aliasi	FGF2
Vanjski ID-jevi	OMIM: 134920 MGI: 95516 HomoloGene: 1521 GeneCards: FGF2
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek)[1] Bend 4q28.1 Početak 122,826,708 bp[1] Kraj 122,898,236 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3 B|3 18.41 cM Početak 37,402,495 bp[2] Kraj 37,464,257 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • cytokine activity • heparin binding • fibroblast growth factor receptor binding • GO:0001948, GO:0016582 vezivanje za proteine • nuclear receptor coactivator activity • chemoattractant activity • growth factor activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • receptor-receptor interaction • integrin binding Ćelijska komponenta • extracellular region • jedro • Vanćelijsko Biološki proces • release of sequestered calcium ion into cytosol • Ćelijska diferencijacija • negative regulation of fibroblast migration • hyaluronan catabolic process • positive regulation of endothelial cell proliferation • positive regulation of MAP kinase activity • negative regulation of blood vessel endothelial cell migration • positive regulation of endothelial cell chemotaxis to fibroblast growth factor • somatic stem cell population maintenance • positive regulation of phospholipase C activity • extracellular matrix organization • Zarastanje rana • negative regulation of cell death • regulation of angiogenesis • nervous system development • cell migration involved in sprouting angiogenesis • MAPK cascade • positive regulation of angiogenesis • positive regulation of phosphatidylinositol 3-kinase activity • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • Hemotaksija • fibroblast growth factor receptor signaling pathway • chondroblast differentiation • multicellular organism development • growth factor dependent regulation of skeletal muscle satellite cell proliferation • branching involved in ureteric bud morphogenesis • positive regulation of cardiac muscle cell proliferation • embryonic morphogenesis • Angiogeneza • positive regulation of cell fate specification • animal organ morphogenesis • regulation of endothelial cell chemotaxis to fibroblast growth factor • phosphatidylinositol biosynthetic process • inositol phosphate biosynthetic process • negative regulation of wound healing • Ras protein signal transduction • positive regulation of cell division • GO:0072468 Transdukcija signala • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive chemotaxis • phosphatidylinositol phosphate biosynthetic process • peptidyl-tyrosine phosphorylation • positive regulation of sprouting angiogenesis • positive regulation of cell population proliferation • phosphatidylinositol-3-phosphate biosynthetic process • stem cell proliferation • regulation of signaling receptor activity • positive regulation of protein kinase B signaling • cytokine-mediated signaling pathway • positive regulation of blood vessel endothelial cell migration • positive regulation of ERK1 and ERK2 cascade • positive regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular endothelial cell proliferation • positive regulation of cell migration involved in sprouting angiogenesis • paracrine signaling • positive regulation of DNA biosynthetic process • positive regulation of endothelial cell chemotaxis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2247	14173
Ensembl	ENSG00000138685	ENSMUSG00000037225
UniProt	P09038	P15655
RefSeq (mRNK)	NM_002006 NM_001361665	NM_008006
RefSeq (bjelančevina)	NP_001997 NP_001348594	NP_032032
Lokacija (UCSC)	Chr 4: 122.83 – 122.9 Mb	Chr 3: 37.4 – 37.46 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

FGF2, znan i kao osnovni fibroblastni faktor rasta (bFGF) i FGF-β, jest faktor rasta, signalni protein koji je kod ljudi kodiran genom FGF2 sa hromosoma 4.^[5][6] Veže se za i vrši efekte preko specifičnih proteina receptora faktora rasta fibroblasta (FGFR) , koji su sami po sebi porodica blisko povezanih molekula. Faktor rasta fibroblasta je prvi put prečišćen 1975. godine; ubrzo nakon toga izolovane su tri varijante: osnovni FGF (FGF2); heparin-vezujući faktor rasta-2; i faktor rasta endotelnih ćelija-2. Sekvenciranje gena je otkrilo da je ova grupa isti protein FGF2 i da je član porodice proteina faktora rasta fibroblasta.^[7][8]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000138685 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000037225 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (septembar 1990). "Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors". The EMBO Journal. 9 (9): 2685–92. doi:10.1002/j.1460-2075.1990.tb07454.x. PMC 551973. PMID 1697263.
6. ^ Kim HS (1998). "Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 83 (1–2): 73. doi:10.1159/000015129. PMID 9925931. S2CID 33214466.
7. ^ Greška kod citiranja: Nevaljana oznaka <ref>; nije naveden tekst za reference s imenom pmid 1785797
8. ^ Burgess WH, Maciag T (1989). "The heparin-binding (fibroblast) growth factor family of proteins". Annual Review of Biochemistry. 58: 575–606. doi:10.1146/annurev.bi.58.070189.003043. PMID 2549857.